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Title   진행성 유방암에서 화학요법제 저항성 인자표출과 조직학적 분화도의 상관관계 ( Correlation of Multidrug resistance Gene Expression with Histologic Grade Expression with Histologic Graed in Locally Advanced Breast Cancer )
Publicationinfo   1993 Jan; 025(03): 376-383.
Key_word   Breast cancer, Chemotherapy
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Abstract   Overexpression of pl70 glycoprotein, the product of the multiple drug resistance(mdr) gene, has been associated with resistance to various cytotoxic drugs used in the treatment of human neoplasms. Benign breast(fibroadenoma) epithelial cells express very weakly p170 as a functon of their secretory capacity. P170 glycoprotein expression was measured in 30 infiltrating ductal carcinomas and 5 fibroadenomas of breast using immunohistochemical staining with the monoclonal antibody C- 219. Staining intensities of the whole tumor and of different area of the cryostat sections were transformed into digital numbers using an algolithm designed for this study. The grade of histological differentiation of cancer cells was classified into well-, moderate-, and poorly- differentiated carcinoma according to Bloom and Richardson's classification. There were 6 cases in grade 1, 18 cases in grade ll, and 6 cases in grade lll. Mean vaiue of mdr gene expression as determined by staining with the C-219 monoclonal antibody was 2.17 in histologic grade 1, 1.94 in grade ll, and 2.00 in grade lll. There was no statistically significant corre- lation between histological grade and mdr gene expression. It was concluded that the level of mdr gene expression as determined by C 219 monoclonai antibody does not correlate with the histological grades in locally advanced breast cancer.
저 자   배정원(Jeoung Won Bae),김인선(In Sun Kim),황정웅(Cheung Wung Whang)